Madrid: Moya, 1899-1904. Two volumes. 8vo. xi, [i], 566; [iv], 1209,  pp., plus 1 leaf of advertisements. FIRST EDITION. With hundreds of text illustrations (a few in colour) from the author’s drawings. Contemporary morocco-backed marbled boards; very minor interior browning, otherwise a very nice copy. Item #14048
First edition. One of the greatest works in the neurosciences, printed by subscription in an edition of only 800 copies. It is here that Cajal laid the cytological and histological foundations of modern neurology. His investigations confirmed the neuron doctrine first proposed by His and Forel, that dendrites receive impulses from other cells, the distinct functional pathways, the synapse, and included an authoritative description of the cerebral cortex leading to cytoarchitectonics.
Ramón y Cajal (1852-1934), neurologist, studied medicine at the University of Zaragoza. He developed and adopted Golgi's chrome-silver method for staining nerve tissues, which allowed him to make very accurate illustrations of nerve cell structure. The research included in the present work led to the Nobel Prize in physiology and medicine shared with Golgi in 1906.