Basel: Joannem Oporini, 1555. Folio (428 x 274 mm). [xii], 505, , 507-824,  pp., including the rare front and back blanks. Second ed. With the famous woodcut title, portrait of Vesalius, 23 full-page and approximately 180 cuts in the text, large and small historiated initials. Complete with the 2 folding plates (bound in) and large printer’s device on verso of last leaf. Modern full calf in a contemporary style, spine in compartments with gilt decorations and morocco label; first 8 and last 2 leaves repaired on the edges, P3 (pp. 437-438) torn on top right corner affecting last word in top 3 lines, otherwise an excellent, clean and wide-margined copy. Item #17327
Second edition containing Vesalius's final revision of the text, along with significant typographical improvements and refinements. Oporinus set this edition in larger type (49 instead of 57 lines per page), which required recutting of all the small initial letters so that they could fit seven lines of new type. He also used heavier and finer paper and improved the presswork so that this second edition would be a superior example of bookmaking (see Norman, II, 2139). According to Choulant-Frank, "the impression of the woodcuts is often clearer and more beautiful than in the previous edition."
This edition contains important corrections and additions. "A fairly full description of the vermiform appendix is added, and of great importance among the alterations is the denial of the permeability of the septum of the heart, thus contributing very substantially to the ultimate discovery of the circulation of the blood" (Tubor Doby, Discoverers of Blood Circulation, pp. 161-64).